Paper

Ultra Sensitive Cytokine Quantification

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Imperacer® (Immuno-PCR) Method Development and Validation for Ultra Sensitive Quantification of Interferon Gamma in Human Plasma to Support Clinical Phase I of a Cancer Vaccine Candidate request reprint
Highly Sensitive Cytokine Quantification using Imperacer®, an Immuno-PCR based Ligand-Binding Assay System request reprint
Development and Validation of an Ultra Sensitive Imperacer (Immuno-PCR) Method for Quantification of Human Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) request reprint
Clinical Biomarker Quantification: Novel Tools for Pharmacodynamic Applications

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Challenges in Developing a Sensitive PD Assay–From Tool Selection to Technologies Evaluation request reprint
Detecting Antigens by Quantitative Immuno-PCR request reprint
An Ultra Sensitive Immuno-qPCR Assay for Quantitation of Intact Pegylated Interferon Beta-1a in Human Serum request reprint
Feasibility of Combinatorial Chemokine Arrays to Study Blood and CSF in Multiple Sclerosis

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Imperacer® pTau Microsampling Bioanalytical Approach Supports Transgenic Mouse CSF Measurement request reprint
Ultrasensitive Multiparameter Biomarker Quantification in Microsampling Support

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Ultrasensitive Biomarker Quantification in Dried Blood Spot Samples request reprint
Technology Comparison of Two Ligand-Binding Assay Platforms for Anti-Drug-Antibody Sample Testing Support for a Non-disclosed Lead Compound: MSD vs. Imperacer request reprint
Comparison of Two Immunoassay Technology Platforms for Bioanalytical Sample Testing Support in PK Profiling of a Non-disclosed Lead Candidate in Diabetes: ELISA vs. Imperacer request reprint
Immuno-PCR as a Clinical Laboratory Tool

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Immuno-PCR: High Sensitivity Detection of Proteins by Nucleic Acid Amplification

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A Real-Time Immuno-PCR Assay for Routine Ultra Sensitive Quantification of Proteins

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Immuno-PCR: a Promising Ultra Sensitive Diagnostic Method to Detect Antigens and Antibodies

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From ELISA to a Novel Immuno-PCR (i-PCR) based Immunogenicity Assay in Quest to Improve the Drug Tolerance request reprint
Challenges in Developing a Sensitive PD Assay–From Tool Selection to Technology Evaluation request reprint
Feasibility of Immuno-PCR Technology Platforms as an Ultra Sensitive Tool for the Detection of Anti-Drug Antibodies

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Emerging Technologies to Increase Ligand Binding Assay Sensitivity

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Immuno-PCR - a Novel Tool for Paleomicrobiology; the Plague Paradigm

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PK

Selection of Critical Reagents for Development of an Ultra Sensitive Immuno-PCR Based Method for Detection of Botulinum Toxin-A in Several Matrices request reprint
Randomized Phase I Trial of the Safety/Tolerability of Anti-Lingo-1 mAB BIIB033

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Phase-I “Proof of Principle”: Immunization with Virosome-Gp41-Derived Antigen Induces Mucosal Antibodies with Antiviral Properties to Reduce Risk of HIV-1 Infection request reprint
Development of an Imperacer Method for Clinical Phase 1a Human Trial of ShK-186, a Specific and Potent Peptide Inhibitor of the Kv1.3 Potassium Channel

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Development of an Immuno-PCR Method with Extreme Robustness against the Presence of Endogenous Counterpart for Clinical PK Study Bioanalytical Support of Replacement Therapy Fc-fusion Protein request reprint
Development and GLP-Validation of Imperacer® (Immuno-PCR) Methods for Ultra Sensitive Quantification of Mucosal Antibodies in Support of Phase-I Clinical Trial for a Novel Vaccination Strategy in Preventing HIV Infection request reprint
Comparison of Two Immunoassay Technology Platforms for Bioanalytical Sample Testing Support in PK Profiling of a Non-disclosed Lead Candidate in Diabetes: ELISA vs. Imperacer request reprint
Pharmacokinetics of Natural Mistletoe Lectins after Subcutaneous Injection

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Adaptation and Performance of an Immuno-PCR Assay for the Quantification of Aviscumine in Patient Plasma Samples

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Phase-I “Proof of Principle”: Immunization with Virosome-Gp41-Derived Antigen Induces Mucosal Antibodies with Antiviral Properties to Reduce Risk of HIV-1 Infection request reprint
Development and GLP-Validation of Imperacer® (Immuno-PCR) Methods for Ultra sensitive Quantification of Mucosal Antibodies in Support of Phase-I Clinical Trial for a Novel Vaccination Strategy in Preventing HIV Infection request reprint
Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes

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Ultra Sensitive Cytokine Quantification

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Imperacer® (Immuno-PCR) Method Development and Validation for Ultra Sensitive Quantification of Interferon Gamma in Human Plasma to Support Clinical Phase I of a Cancer Vaccine Candidate request reprint
Highly Sensitive Cytokine Quantification using Imperacer®, an Immuno-PCR based Ligand-Binding Assay System request reprint
Development and Validation of an Ultra Sensitive Imperacer (Immuno-PCR) Method for Quantification of Human Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) request reprint
Challenges in Developing a Sensitive PD Assay–From Tool Selection to Technology Evaluation request reprint
An Ultrasensitive Immuno-qPCR Assay for Quantitation of Intact Pegylated Interferon Beta-1a in Human Serum request reprint
Imperacer® (Immuno-PCR) Method Development and Validation for Ultra Sensitive Quantification of Interferon Gamma in Human Plasma to Support Clinical Phase I of a Cancer Vaccine Candidate request reprint
Detection of Rotavirus from Stool Samples using a Standardized Immuno-PCR (Imperacer) Method with End-Point and Real-Time Detection

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Analysis of the Effects of Androgens and Training on Myostatin Propeptide and Follistatin Concentrations in Blood and Skeletal Muscle using Highly Sensitive Immuno-PCR

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Modulation of Follistatin and Myostatin Propeptide by Anabolic Steroids and Gender

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An Experimental Mouse Model to Establish Tropheryma Whipplei as a Diarrheal Agent

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Immuno-PCR-a New Tool for Paleomicrobiology: the Plague Paradigm

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Development and Assessment of Sensitive Immuno-PCR Assays for the Quantification of Cerebrospinal Fluid Three- and Four- Repeat Tau Isoforms in Tauopathies

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Phase I Trial of Intravenous Aviscumine (rViscumin) in Patients with Solid Tumors: a Study of the European Organization for Research and Treatment of Cancer New Drug Development Group

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Immuno-PCR based Quantification of Multiple Phosphorylated Tau-Epitopes linked to Alzheimer's Disease

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Imperacer® pTau Microsampling Bioanalytical Approach Supports Transgenic Mouse CSF Measurement request reprint
Blood Monocyte Levels of New Mid-Domain Beta-Amyloid-Degradation-Based Peptide Correlates Strongly with CSF Biomarkers request reprint
Immuno-PCR for the Early Serological Diagnosis of an Acute Infectious Disease: the Q Fever Paradigm

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PD

Clinical Biomarker Quantification: Novel Tools for Pharmacodynamic Applications

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Challenges in Developing a Sensitive PD Assay–From Tool Selection to Technologies Evaluation request reprint

A broader scope of Imperacer case studies and peer-reviewed publications are available upon request.

Please feel free to contact Chimera Biotec’s team of dedicated scientists for more in-depth information. We are looking forward to provide you with the immunoassay to exceed your highest expectations.