Microfluidic by BMBF
Biogenic magnetite nanoparticles for microarray and separation technology
Dr. Mark Spengler and his team at Chimera Biotec GmbH coordinate a project for the production and development of semisynthetic biogenic magnetnanoparticles and their use for analytical and preparative applications. The other members of the project team are PD Dr. Schüler (Ludwig Maximilians University Munich), Prof. Niemeyer (University of Technology Dortmund) and Molzym GmbH & Co.KG. The project is sponsored by the Bundesministerium für Bildung und Forschung (BMBF), Germany.
In spite of the enormous potential of biogenic magnetite nanoparticles, the in vivo biomineralisation has so far only being used in a few laboratories as a method for the fabrication of nanoparticles for biolabeling and bioseparation purposes. Our system is based on magnetosom nanoparticles, produced by fermentation of magnetotactic bacteria, and their subsequent modification with functional biomolecules in vitro using chemical synthetic methods.
We here work on the application of synthetic and semisynthetic biogenic magnetnanoparticles. The magnetnanoparticles will be used for the development of novel protein microarrays based on DNA-directed immobilization and as tool in analytical technologies like ultrasensitive Immuno-PCR.
